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    S

    Septerna, Inc. Common Stock (SEPN)

    Official site

    HEALTHCARE • BIOTECHNOLOGY • NASDAQ

    $36.41
    -1.15 (-3.05%)

    Market Cap: $1.70B

    Last updated: Oct 16, 2026 at 1:55 PM ET

    Earnings

    Performance (10Y)

    Beat Rate
    50%(4/8)
    Avg Surprise
    -115.70%
    Streak
    3 Q

    Upcoming Estimates

    Period ending Sep 30, 2026
    EPS Consensus$-0.40
    Range$-0.69 - $-0.24
    4 analysts
    EPS RevisionsNo revisions (7d)
    2
    1
    30d
    EPS Estimate DriftChange to current
    90d ago$-0.55+28.2%
    60d ago$-0.55+28.2%
    30d ago$-0.41+4.0%
    7d ago$-0.400.0%
    Current$-0.40
    Revenue Consensus
    $21M
    Range$0 - $32M
    10 analysts
    Period ending Dec 31, 2026
    EPS Consensus$-0.02
    Range$-0.20 - $0.13
    4 analysts
    Revenue Consensus
    $41M
    Range$-1791110 - $63M
    10 analysts
    PeriodReportedEst.SurpriseB/MYoY
    Dec 26EST
    		-$-0.02---
    Sep 26EST
    		-$-0.40---
    Jun 26
    Reported Aug 10
    		$-0.29$-0.48+39.58%Beat+48.2%
    Mar 26
    Reported May 12
    		$-0.19N/A+56.82%Beat+61.2%
    Dec 25
    Reported Mar 9
    		$-0.24N/A+66.67%Beat+62.5%
    Sep 25
    Reported Nov 10
    		$-0.10N/A-112.66%Miss+98.8%
    Jun 25
    Reported Aug 11
    		$-0.56$0.93-160.22%Miss+95.6%
    Mar 25
    Reported May 15
    		$-0.49$-0.38-28.95%Miss-
    Dec 24
    Reported Mar 27
    		$-0.64$-0.69+6.80%Beat-
    Sep 24
    Reported Nov 7
    		$-8.40$-0.94-793.62%Miss-
    Jun 24
    Reported Aug 28
    		$-12.76$0.00N/AMiss-

    Key Metrics

    Valuation
    P/E Ratio-44.41EV/EBITDAN/A
    Price/FCFN/AFCF YieldN/A
    Profitability
    Profit Margin-24.50%Operating Margin-62.90%
    ROE-6.34%ROICN/A
    Financial Health
    Debt/Equity0.00xInterest CoverageN/A
    Current Ratio4.99xQuick Ratio4.99x
    Trading Statistics
    BetaN/AAvg Volume412.77K
    52-Week High$51.1052-Week Low$17.55

    Technical Indicators Dashboard

    Moving Averages

    SMA 10$37.37
    SMA 20$38.12
    SMA 50$39.48
    SMA 200$31.19
    EMA 10$37.39
    EMA 20$37.85
    EMA 50$37.84
    EMA 200$31.67

    MACD

    Line: -0.50Signal: -0.37Hist: -0.13

    ADX

    ADX: 10.7+DI: 15.4-DI: 20.6

    Aroon & PSAR

    Aroon Up40.0
    Aroon Down88.0
    PSAR$34.66

    Bollinger Bands

    Upper Band$40.55
    Lower Band$35.69
    %B Position1274%(Upper)
    Band Width0.15

    RSI (14-Day)

    Neutral
    43.2

    Momentum Oscillators

    Stoch %K48.0
    Stoch %D43.9
    Williams %R-66.2
    ROC (10d)-6.9%
    Momentum-2.71
    CCI (20d)-86.3
    MFI (14d)38.9

    Volatility Measures

    ATR (14d)$2.02(5.5%)
    StdDev (20d)1.21
    Hist Vol47.1%(High)

    Volume Flow

    VWAP$37.07
    OBV41.0M
    AD Line9.0M
    CMF (20d)-0.073

    Volume Metrics

    Avg Vol (20d)422.8K
    Vol Ratio1.2x
    VWMA (20d)$37.85

    Pivot Points

    R3$39.39
    R2$38.90
    R1$38.23
    Pivot Point$37.74
    S1$37.07
    S2$36.58
    S3$35.91

    Advanced Oscillators

    TSI-8.25
    Ultimate Osc47.2
    KST-58.27

    Financial Data

    QuarterJun 2026Mar 2026Dec 2025Sep 2025Jun 2025Mar 2025Dec 2024Sep 2024Jun 2024Mar 2024Dec 2023Sep 2023
    Total Revenue$26.75M$26.52M$24.12M$21.50M$119,000$219,000$212,000$176,000$370,000$317,000$118,000$33,000
    Cost of Revenue$0$0$401,000$0$0$0N/A$0$0$0N/A$0
    Gross Profit$26.75M$26.52M$24.12M$21.50M$119,000$219,000$212,000$176,000$370,000$317,000$118,000$33,000
    Operating Expenses$43.58M$39.82M$40.14M$18.88M$29.10M$26.13M$24.93M$22.73M$18.43M$15.81M$-34,199,000$12.07M
    R&D$35.13M$29.54M$31.86M$24.26M$22.19M$19.27M$19.32M$17.83M$15.04M$13.15M$10.33M$9.28M
    SG&A$8.45M$10.29M$8.28M$7.12M$6.91M$6.86M$5.61M$4.89M$3.40M$2.65M$3.10M$2.79M
    Operating Income$-16,836,000$-13,300,000$-16,023,000$2.61M$-28,978,000$-25,910,000$-24,718,000$-22,550,000$-18,065,000$-15,490,000$34.32M$-12,040,000
    Interest Income$4.80M$5.03M$5.34M$5.57M$4.17M$4.46M$3.91M$1.90M$1.53M$1.28M$1.25M$1.10M
    Interest Expense$0$0$0$0$0$0$0$0$0$0$0$0
    Income Before Tax$-12,061,000$-8,300,000$-10,726,000$8.17M$-24,838,000$-21,476,000$-20,828,000$-20,659,000$-16,550,000$-14,259,000$35.59M$-10,945,000
    Income Tax Expense$973,000$337,000$12,000$0$0$0$-564,000$-136,000$109,000$93,000$691,000$0
    Net Income$-13,034,000$-8,637,000$-10,738,000$8.17M$-24,838,000$-21,476,000$-20,668,000$-20,523,000$-16,441,000$-14,166,000$34.89M$-10,945,000
    EBITDA$-16,894,000$-13,665,000$-16,550,000$2.39M$-29,573,000$-26,506,000$-25,157,000$-22,566,000$-17,905,000$-15,294,000$-13,065,000$-12,041,000
    EBIT$-16,859,000$-13,331,000$-16,064,000$2.61M$-29,003,000$-25,938,000$-24,736,000$-22,559,000$-18,080,000$-15,538,000$-13,308,000$-12,041,000
    * Some calculated fields are derived from available data when not provided by source

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    News

    Officer Daniel Long proposes selling 10,001 Septerna (SEPN) common shares.

    Septerna officer Daniel Long has proposed selling 10,001 common shares of SEPN, valued at approximately $391,339.13, with an approximate sale date of October 1...

    Stock Titan•10/2/26•Neutral

    Septerna Officer Samira Shaikhly Files Form 144 to Sell 12,592 Common Shares

    Septerna officer Samira Shaikhly has filed a Form 144 to sell 12,592 shares of the company's common stock, valued at over $492,000. These shares were acquired through the exercise of stock options on October 1, 2026...

    Kalkine Media•10/1/26•Neutral

    An officer proposes selling 12,592 Septerna (SEPN) shares acquired by exercising stock options.

    Septerna, Inc. officer Samira Shaikhly has proposed selling 12,592 common shares with an aggregate market value of $492,724.96. These shares were acquired on October 1, 2026...

    Stock Titan•10/1/26•Neutral

    Septerna (SEPN) Heads To Healthcare Conferences, Is The Valuation Already Too Rich?

    Septerna (SEPN) is attending upcoming healthcare conferences, generating investor interest despite recent share price fluctuations. While the company shows strong long-term momentum...

    Yahoo! Finance Canada•9/14/26•Somewhat-Bearish

    Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

    Septerna, Inc. announced an inducement grant of a non-qualified stock option to purchase up to 275,000 shares of its common stock to its new Chief Medical Officer, Rajiv Patni, M.D. This grant, effective September 8...

    The Manila Times•9/10/26•Somewhat-Bullish

    SEPN Valuation and Fair Value

    P/E
    -44.4x
    Forward P/E
    107.5x
    P/B
    4.2x
    See GNG's fair value

    SEPN Profitability: Margins, ROIC and FCF

    Gross margin
    100.0%
    Operating margin
    -62.9%
    Net margin
    -24.5%
    ROE
    -6.3%
    FCF margin
    106.3%

    SEPN Competitors

    CompanyTicker
    Personalis IncPSNL
    Dentsply Sirona IncXRAY
    Trevi Therapeutics IncTRVI
    Intellia Therapeutics IncNTLA
    Alignment Healthcare LLCALHC
    Novocure LtdNVCR
    Sonida Senior Living IncSNDA
    Azenta IncAZTA

    Sector: Healthcare

    SEPN Analyst Ratings

    Consensus
    Buy
    Analysts
    10
    Strong Buy
    1
    Buy
    9
    Hold
    0
    Sell
    0
    Strong Sell
    0

    SEPN Bull Case vs Bear Case

    Bull case

    • SEPN converts 106.3% of revenue into free cash flow.
    • SEPN grew quarterly revenue 22376.0% year over year.
    • 100.0% of SEPN's analyst ratings are Buy or Strong Buy.

    Bear case

    • SEPN has a -24.5% net profit margin.

    SEPN Earnings: Beat Rate and Next Report

    Beat rate
    4 of 8 quarters (50.0%)
    Average surprise
    -115.7%
    EPS estimate (fiscal period ending Sep 30, 2026)
    $-0.40
    Estimate revisions (30 days, fiscal period ending Sep 30, 2026)
    2 up, 1 down

    Frequently Asked Questions About SEPN

    Does SEPN pay dividends?

    Septerna, Inc. Common Stock (SEPN) does not currently pay a regular dividend.

    What is SEPN's market cap?

    Septerna, Inc. Common Stock (SEPN) has a market capitalization of $1.70B with a current stock price of $36.41.

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    Sector: Healthcare

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