Skip to main content
    S

    State Street SPDR S&P Biotech ETF (XBI) Holdings

    Sector Equity • Biotechnology

    $152.23
    +3.83 (+2.58%)

    Market Cap: $10.40B

    Last updated: Nov 06, 2026 at 4:42 PM ET

    XBI holds 157 holdings. The largest holding is Moderna Inc at 2.27%; the top 10 make up 17.76% of the fund in GNG's holdings data, updated Nov 5, 2026.

    XBI Top 10 Holdings

    RankNameWeightCumulative share
    1Moderna Inc2.27%2.27%
    2Twist Bioscience Corp1.99%4.26%
    3Natera Inc1.85%6.11%
    4Halozyme Therapeutics Inc1.74%7.85%
    5Biogen Inc1.67%9.52%
    6Amgen Inc1.66%11.18%
    7United Therapeutics Corporation1.66%12.84%
    8Spyre Therapeutics Inc.1.65%14.49%
    9AbbVie Inc1.64%16.13%
    10Exelixis Inc1.63%17.76%

    XBI Sector Breakdown

    Healthcare96.5%

    All 157 XBI Holdings

    Holdings updated Nov 5, 2026
    1MRNAModerna Inc2.27%
    2TWSTTwist Bioscience Corp1.99%
    3NTRANatera Inc1.85%
    4HALOHalozyme Therapeutics Inc1.74%
    5BIIBBiogen Inc1.67%
    6AMGNAmgen Inc1.66%
    7UTHRUnited Therapeutics Corporation1.66%
    8SYRESpyre Therapeutics Inc.1.65%
    9ABBVAbbVie Inc1.64%
    10EXELExelixis Inc1.63%
    11IOVAIovance Biotherapeutics Inc1.62%
    12GILDGilead Sciences Inc1.57%
    13GRALGRAIL, LLC1.51%
    14ORKAOruka Therapeutics, Inc.1.51%
    15TGTXTG Therapeutics Inc1.51%
    16VRTXVertex Pharmaceuticals Inc1.46%
    17REGNRegeneron Pharmaceuticals Inc1.45%
    18ALKSALKERMES PLC1.43%
    19CRSPCrispr Therapeutics AG1.43%
    20PTGXProtagonist Therapeutics Inc1.40%
    21NBIXNeurocrine Biosciences Inc1.35%
    22BBIOBridgeBio Pharma Inc1.34%
    23PTCTPTC Therapeutics Inc1.34%
    24INCYIncyte Corporation1.33%
    25KRYSKrystal Biotech Inc1.33%
    26RVMDRevolution Medicines Inc1.31%
    27ALNYALNYLAM PHARMACEUTICALS INC1.30%
    28KYMRKymera Therapeutics Inc1.28%
    29ROIVRoivant Sciences Ltd1.28%
    30BMRNBIOMARIN PHARMACEUTICAL INC1.25%
    31ERASErasca Inc1.23%
    32COGTCogent Biosciences Inc1.22%
    33KODKodiak Sciences Inc1.21%
    34CYTKCytokinetics Inc1.19%
    35PCVXVaxcyte Inc1.19%
    36PRAXPraxis Precision Medicines Inc1.19%
    37IONSIonis Pharmaceuticals Inc1.15%
    38VCYTVeracyte Inc1.14%
    39MDGLMadrigal Pharmaceuticals Inc1.13%
    40DNTHDianthus Therapeutics Inc.1.11%
    41TVTXTravere Therapeutics Inc1.10%
    42INSMInsmed Inc1.08%
    43RYTMRhythm Pharmaceuticals Inc1.06%
    44ARWRARROWHEAD PHARMACEUTICALS INC1.05%
    45MIRMMirum Pharmaceuticals Inc1.03%
    46IBRXImmunitybio Inc1.00%
    47BEAMBeam Therapeutics Inc0.96%
    48CGONCG Oncology, Inc. Common stock0.96%
    49CDNACareDx Inc0.93%
    50RLAYRELAY THERAPEUTICS INC ORDINARY SHARES0.93%
    51ARQTArcutis Biotherapeutics Inc0.92%
    52TNGXTango Therapeutics Inc0.88%
    53RAREUltragenyx0.85%
    54VKTXViking Therapeutics Inc0.85%
    55CELCCelcuity LLC0.81%
    56SRRKScholar Rock Holding Corp0.77%
    57DYNDyne Therapeutics Inc0.72%
    58RXRXRecursion Pharmaceuticals Inc0.70%
    59AGIOAGIOS PHARMACEUTICALS INC0.63%
    60IMVTImmunovant Inc0.60%
    61VRDNViridian Therapeutics Inc0.59%
    62IRONDisc Medicine Inc.0.58%
    63NRIXNurix Therapeutics Inc0.58%
    64PURRHyperliquid Strategies Inc Common Stock0.58%
    65ABSIABSCI CORP0.57%
    66DNLIDenali Therapeutics Inc0.57%
    67SLSSellas Life Sciences Group Inc0.57%
    68BCRXBioCryst Pharmaceuticals Inc0.56%
    69BHVNBiohaven Ltd.0.56%
    70NTLAIntellia Therapeutics Inc0.56%
    71SMMTSummit Therapeutics PLC0.56%
    72SRPTSarepta Therapeutics Inc0.56%
    73VERAVera Therapeutics Inc0.55%
    74IDYAIdeaya Biosciences Inc0.52%
    75PVLAPalvella Therapeutics, Inc0.52%
    76ADMAADMA BIOLOGICS INC0.50%
    77ACADACADIA PHARMACEUTICALS INC0.49%
    78QUREUniqure NV0.49%
    79CLDXCelldex Therapeutics Inc0.46%
    80NVAXNovavax Inc0.46%
    81VCELVericel Corp Ord0.44%
    82REPLReplimune Group Inc0.39%
    83TRAXFIRST TRACKS BIOTHERAPEUTICS INC0.39%
    84XNCRXencor Inc0.38%
    85NKTRNektar Therapeutics0.37%
    86RCUSArcus Biosciences Inc0.37%
    87IMNMIMMUNOME INC ORDINARY SHARES0.36%
    88SNDXSyndax Pharmaceuticals Inc0.36%
    89PGENPrecigen Inc0.34%
    90STOKStoke Therapeutics Inc0.34%
    91ANABANAPTYSBIO INC0.31%
    92MLYSMineralys Therapeutics, Inc. Common Stock0.31%
    93VIRVir Biotechnology Inc0.30%
    94ZBIOZenas BioPharma, Inc. Common Stock0.29%
    95KURAKura Oncology Inc0.27%
    96JBIOJade Biosciences, Inc.0.24%
    97MNKDMannKind Corp0.24%
    98TYRATyra Biosciences Inc0.24%
    99ANNXAnnexon Inc0.23%
    100INBXInhibrx Biosciences, Inc.0.23%
    Showing 1-100 of 157
    Show:

    Holdings questions

    What holdings are in XBI?

    XBI holds 157 holdings. The largest holdings are Moderna Inc (2.27%), Twist Bioscience Corp (1.99%) and Natera Inc (1.85%).

    What are XBI's top 10 holdings?

    Moderna Inc (2.27%), Twist Bioscience Corp (1.99%), Natera Inc (1.85%), Halozyme Therapeutics Inc (1.74%), Biogen Inc (1.67%), Amgen Inc (1.66%), United Therapeutics Corporation (1.66%), Spyre Therapeutics Inc. (1.65%), AbbVie Inc (1.64%), Exelixis Inc (1.63%). Together they make up 17.76% of the fund.

    How many holdings does XBI have?

    XBI has 157 holdings in GNG's holdings data.

    Which sector does XBI invest in most?

    Healthcare is the largest listed sector at 96.5%.

    When did GNG last update XBI's holdings?

    GNG last updated XBI's holdings on Nov 5, 2026.